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PE 154

CAS No. 1192750-33-6

PE 154( —— )

Catalog No. M33905 CAS No. 1192750-33-6

PE 154 is a potent fluorescent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 280 pM and 16 nM respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    PE 154
  • Note
    Research use only, not for human use.
  • Brief Description
    PE 154 is a potent fluorescent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 280 pM and 16 nM respectively.
  • Description
    PE154 (Compound 13) is a potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50s=280 pM and 16 nM, respectively). PE154 can label β-amyloid plaques in histochemical analysis.
  • In Vitro
    ——
  • In Vivo
    PE154 (hippocampus injection; 0.2 μg per mouse; once) can stain the histochemical of cortical βamyloid plaques.Animal Model:13–20-month-old triple-transgenic mice harbouring three mutant genes (APPswe, PS-1 and tauP301L)Dosage:0.2 μg per mouse Administration:Hippocampus injection; 0.2 μg per mouse; once Result:Showed the histochemical staining of cortical βamyloid plaques in triple-transgenic (TTG) mice.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    AChE
  • Recptor
    AChE
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1192750-33-6
  • Formula Weight
    589.68
  • Molecular Formula
    C35H35N5O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 8.33 mg/mL (14.13 mM; Ultrasonic (<60°C)
  • SMILES
    N(NC(CC1=CC=C(NC=C2C(=O)C=3C(OC2=O)=CC(N(CC)CC)=CC3)C=C1)=O)C4=C5C(=NC=6C4=CC=CC6)CCCC5
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Paul W Elsinghorst, et al. A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques. Org Biomol Chem. 2009 Oct 7;7(19):3940-6.?
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